Binder (2011)

Binder, J. R., Gross, W. L., Allendorfer, J. B., Bonilha, L., Chapin, J., Edwards, J. C., Grabowski, T. J., Langfitt, J. T., Loring, D. W., Lowe, M. J., Koenig, K., Morgan, P. S., Ojemann, J. G., Rorden, C., Szaflarski, J. P., Tivarus, M. E., & Weaver, K. E. (2011). Mapping anterior temporal lobe language areas with fMRI: A multicenter normative study. NeuroImage, 54(2), 1465–1475. https://doi.org/10.1016/j.neuroimage.2010.09.048

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Binder (2011)

Core argument: A Story > Math fMRI contrast provides a reliable, multicenter-validated method for mapping anterior temporal lobe (ATL) language regions. Story comprehension (auditory short narratives from Aesop’s fables, followed by 2-AFC comprehension questions) reliably activates bilateral ATL, including lateral, inferior, and polar temporal regions, which a semantic arithmetic control task does not.

Methods:

• Story task: short Aesop’s fable stories presented via MRI-compatible headphones, followed by a 2-alternative forced-choice question testing story content
• Math task: active attentional control — serial addition/subtraction problems, 2-AFC response (used to cancel non-semantic auditory/attentional activations)
• Initial cohort N = 18 at Medical College of Wisconsin; validated across 6 further sites (N = 77 total across 7 US centers)
• Analysis: Story > Math contrast at group level; cluster threshold p < .005 corrected

Key results:

• Story > Math robustly activated lateral and inferior ATL bilaterally, as well as medial temporal regions
• Results replicated across all 7 imaging centers despite differences in scanner vendor, field strength, and head coil
• Established this paradigm as a reliable functional localizer for language/semantic regions in the ATL

Why relevant to thesis:
The HCP Language Task (used in §3.4.2.1 / §4.6.1 for behavioral prediction of ‘what’-stream efficiency) is directly derived from this Binder et al. (2011) paradigm — same story stimuli (Aesop’s fables), same 2-AFC question format, same Story > Math contrast logic. Barch et al. (2013) cite Binder et al. (2011) explicitly as the source of the HCP Language Task design.

Relevance to thesis:

• Cite in §3.4.2.1 as the source for the HCP Language Story task design
• The story accuracy and story reaction time measures used for the ‘what’-stream behavioral prediction derive their validity from this normative study

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BibTeX:

@article{binder2011,
  author    = {Binder, Jeffrey R. and Gross, William L. and Allendorfer, Jane B. and
               Bonilha, Leonardo and Chapin, Jessica and Edwards, Jonathan C. and
               Grabowski, Thomas J. and Langfitt, John T. and Loring, David W. and
               Lowe, Mark J. and Koenig, Katherine and Morgan, Paul S. and
               Ojemann, Jeffrey G. and Rorden, Christopher and Szaflarski, Jerzy P. and
               Tivarus, Madalina E. and Weaver, Kurt E.},
  title     = {Mapping anterior temporal lobe language areas with {fMRI}:
               A multicenter normative study},
  journal   = {NeuroImage},
  year      = {2011},
  volume    = {54},
  number    = {2},
  pages     = {1465--1475},
  doi       = {10.1016/j.neuroimage.2010.09.048}
}

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Created: 2026-05-01